Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus
| Autor: | Mattis B. Wigestrand, Robert M. Sears, Ann E. Fink, Claudia R. Farb, Luis de Lecea, Joseph E. LeDoux |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Patch-Clamp Techniques Conditioning Classical Optogenetics Amygdala Arousal Rats Sprague-Dawley Channelrhodopsins mental disorders medicine Animals Learning Urea Fear conditioning Naphthyridines Benzoxazoles Orexins Multidisciplinary digestive oral and skin physiology Neuropeptides Intracellular Signaling Peptides and Proteins Fear Biological Sciences Orexin Rats medicine.anatomical_structure nervous system Acoustic Stimulation Hypothalamus Locus coeruleus Anxiety Locus Coeruleus medicine.symptom Psychology Neuroscience hormones hormone substitutes and hormone antagonists psychological phenomena and processes |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 110(50) |
| ISSN: | 1091-6490 |
| Popis: | Survival in a dangerous environment requires learning about stimuli that predict harm. Although recent work has focused on the amygdala as the locus of aversive memory formation, the hypothalamus has long been implicated in emotional regulation, and the hypothalamic neuropeptide orexin (hypocretin) is involved in anxiety states and arousal. Nevertheless, little is known about the role of orexin in aversive memory formation. Using a combination of behavioral pharmacology, slice physiology, and optogenetic techniques, we show that orexin acts upstream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning, specifically during the aversive event. Our results are consistent with clinical studies linking orexin levels to aversive learning and anxiety in humans and dysregulation of the orexin system may contribute to the etiology of fear and anxiety disorders. |
| Databáze: | OpenAIRE |
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