[Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia]
| Autor: | Petr Dmitriyevich Shabanov, A.V. Lizunov, E. R. Bychkov, A. A. Lebedev, S. V. Orlov, I.V. Okunevich, L. B. Piotrovskiy |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject Hyperlipidemias Normal values Pharmacology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fenofibrate APOA1 Gene Hyperlipidemia medicine Animals Triglycerides media_common Hypolipidemic Agents biology Apolipoprotein A-I Cholesterol Imidazoles General Medicine medicine.disease Rats 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) Apolipoprotein A1 medicine.drug |
| Zdroj: | Biomeditsinskaia khimiia. 65(5) |
| ISSN: | 2310-6972 |
| Popis: | An imidazole derivative cramizol, has lipid-lowering and anti-atherogenic effects. Cramizol reduces blood levels of cholesterol and triglycerides, and also reduces the atherogenic index in animals with acute hyperlipidemia induced by Triton WR-1339. Cramizol and the lipid-lowering drug fenofibrate exhibited similar effectiveness as hypolipidemic agents. Cramizol also restores the expression of theiApoa1/igene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action.Proizvodnoe imidazola kramizol obladaet tsitoprotektornym, gipolipidemicheskim i antiaterogennym deĭstviem. Na modeli ostroĭ giperlipidemii, indutsirovannoĭ detergentom tritonom WR-1339, étot preparat snizhaet soderzhanie kholesterina i triglitseridov v krovi, a takzhe znachitel'no umen'shaet kholesterinovyĭ indeks aterogennosti. Po vyrazhennosti gipolipidemicheskogo deĭstviia kramizol sootvetstvuet étalonnomu gipolipidemicheskomu preparatu fenofibratu. Kramizol takzhe vosstanavlivaet do normal'nykh znacheniĭ ékspressiiu genaiApoa1/iv pecheni u krys s éksperimental'no indutsirovannoĭ ostroĭ giperlipidemieĭ, chto, vozmozhno, iavliaetsia osnovoĭ ego gipolipidemicheskogo i antiaterogennogo deĭstviia. |
| Databáze: | OpenAIRE |
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