MALT1 positively relates to Th17 cells, inflammation/activity degree, and its decrement along with treatment reflects TNF inhibitor response in ankylosing spondylitis patients
| Autor: | Jie Yuan, Lei Xiang, Feng Wang, Lin Zhang, Gaozhan Liu, Xiuli Chang, Anbing Zhang, Ying Tao |
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| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Inflammation Biochemistry (medical) Clinical Biochemistry Interleukin-17 Public Health Environmental and Occupational Health Hematology Lymphoma B-Cell Marginal Zone Th1 Cells Medical Laboratory Technology Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Osteoarthritis Leukocytes Mononuclear Immunology and Allergy Humans Th17 Cells Spondylitis Ankylosing Tumor Necrosis Factor Inhibitors |
| Zdroj: | Journal of clinical laboratory analysis. 36(7) |
| ISSN: | 1098-2825 |
| Popis: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) facilitates CD4This study recruited 73 AS patients underwent adalimumab treatment. Peripheral blood mononuclear cell (PBMC) was obtained at Week (W) 0, W4, W8, and W12 after treatment initiation; then, MALT1 was measured using RT-qPCR. Furthermore, PBMC and serum at W0 were proposed to flow cytometry and ELISA for Th1 cells, Th17 cells, IFN-γ, and IL-17A levels measurement. Besides, 20 osteoarthritis patients and 20 healthy controls (HCs) were enrolled to detect MALT1.Mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression was higher in AS patients compared with HCs (p 0.001) and osteoarthritis patients (p 0.001). Besides, MALT1 expression was positively linked with CRP (p = 0.002), BASDAI (p = 0.026), PGADA (p = 0.040), ASDASMucosa-associated lymphoid tissue lymphoma translocation protein 1 positively correlates with Th17 cells, inflammatory, and activity degree; meanwhile, its decrement along with treatment reflects the response to TNF inhibitor in AS patients. |
| Databáze: | OpenAIRE |
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