The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein
Autor: | Zhouke Guo, Haobin Cai, Lijin Liu, Cong Yang, Tiantian Cai, Xile Pang, Huafeng Pan, Liuchang Zhou, Yi-Jie Wang, Qi Wang, Qinkai Zhan, Haotao Zheng |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Aging Traditional Chinese medicine Pharmacology Neuroprotection 03 medical and health sciences 0302 clinical medicine Memory medicine Animals Dementia Cognitive Dysfunction Medicine Chinese Traditional Cognitive impairment business.industry medicine.disease LRP1 Danggui-shaoyao-san Rats Lipoproteins LDL Neuroprotective Agents 030104 developmental biology LDL receptor Geriatrics and Gerontology business 030217 neurology & neurosurgery |
Zdroj: | Rejuvenation Research. 23:420-433 |
ISSN: | 1557-8577 1549-1684 |
Popis: | Effective drugs for treating dementia are still rare. Danggui-Shaoyao San (DSS), a traditional Chinese medicine, has been widely used in oriental countries for the treatment of various gynecological diseases. Many studies reported that DSS could ameliorate cognitive impairment. In this study, we aimed to investigate the underlying mechanism of DSS on vascular cognitive impairment (VCI) rats. Chronic cerebral hypoperfusion (CCH) is one of the main causes of VCI. CCH resulted in a chain of pathological process, including neuroinflammation, neuronal apoptosis, and oxidative stress. The most widely used animal model of VCI is permanent bilateral common carotid artery occlusion in rats. In this research, we determined whether DSS attenuated cognitive impairment by targeting I kappa B kinase (IKK)/nuclear factor of kappa B (NF-κB) signal pathway in VCI rats. Morris water maze and fear conditioning tests results indicated that DSS [7.2 g/(kg·d)] could improve learning and memory ability in VCI rats. We also found DSS significantly elevated the levels of low-density lipoprotein receptor-related protein 1 (LRP1) in the brain of VCI rats and this might indirectly target the IKK/NF-κB signal pathway to exert inhibitory effect on neuroinflammation, neuronal apoptosis, and oxidative stress in VCI rats. The present researches indicated that DSS might attenuate cognitive impairment by targeting IKK/NF-κB signal pathway in VCI rats and DSS might be a promising agent on VCI. |
Databáze: | OpenAIRE |
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