Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs
| Autor: | Nicola Stock, Steve Goodbourn, B. Precious, Kathrin Hagmaier, Lin-Fa Wang, Richard E. Randall, Kay Childs |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Cytoplasm
Molecular Sequence Data Active Transport Cell Nucleus Transcription factor complex Electrophoretic Mobility Shift Assay Virus Cell Line 03 medical and health sciences Viral Proteins Interferon Virology medicine Animals Humans Electrophoretic mobility shift assay Amino Acid Sequence Rubulavirus Phosphorylation Mononegavirales 030304 developmental biology Cell Nucleus 0303 health sciences biology Base Sequence Animal 030302 biochemistry & molecular biology Interferon-Stimulated Gene Factor 3 biology.organism_classification 3. Good health STAT Transcription Factors Microscopy Fluorescence STAT protein Interferons medicine.drug |
| Zdroj: | The Journal of General Virology |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | Mapuera virus(MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genusRubulaviruson the basis of structural and genetic features. Like other rubulaviruses it encodes a V protein (MPRV/V) that functions as an interferon (IFN) antagonist. Here we show that MPRV/V differs from the IFN antagonists of other rubulaviruses in that it does not induce the proteasomal degradation of STAT proteins, key factors in the IFN signalling cascade. Rather, MPRV/V prevents the nuclear translocation of STATs in response to IFN stimulation and inhibits the formation of the transcription factor complex ISGF3. We also show that MPRV/V blocks IFN signalling in cells from diverse mammalian species and discuss the IFN response as a barrier to cross-species infections. |
| Databáze: | OpenAIRE |
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