Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy
| Autor: | Pravin D. Potdar, Shahid Chaudhary |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Cell Cancer General Medicine Disease Immunotherapy Pharmacology Biology medicine.disease 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Cancer cell medicine Cancer research Ectopic expression Induced pluripotent stem cell Reprogramming |
| Zdroj: | Applied Cancer Research. 37 |
| ISSN: | 1980-5578 |
| DOI: | 10.1186/s41241-017-0015-y |
| Popis: | Induced Pluripotent Stem Cells (iPSCs) technology has catapulted the field of stem-cell biology through ectopic expression of reprogramming factors. Ever since its discovery, the potential of iPSCs has been explored by many scientists to unravel the molecular mechanism responsible for cancer initiation and progression. Besides modeling cancer, the further applications of this technology includes high-throughput drug screening, epigenetic reprogramming of cancer cell state to normal, immunotherapy and regenerative cell therapies. Here, we review the current challenges on clinical applications of iPSCs with respect to understanding cancer and personalizing treatment for the disease. |
| Databáze: | OpenAIRE |
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