Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis
| Autor: | Bavouma Charles Sombié, B. Gérard Josias Yameogo, Moustapha Ouedraogo, Réné Flore Gueu Gondi, Rasmané Semdé |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Thermogravimetric analysis
medicine.medical_specialty Chemistry Liquid crystalline osteointegrator material lcsh:RM1-950 in vitro characterization implants lcsh:RS1-441 Drug release Surgery lcsh:Pharmacy and materia medica Gentamicin Sulfate lcsh:Therapeutics. Pharmacology Chronic osteomyelitis liquid crystalline medicine Gentamicin Original Article Implant Dissolution medicine.drug Biomedical engineering |
| Zdroj: | Journal of Advanced Pharmaceutical Technology & Research Journal of Advanced Pharmaceutical Technology & Research, Vol 3, Iss 2, Pp 100-105 (2012) |
| ISSN: | 0976-2094 2231-4040 |
| Popis: | Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis. |
| Databáze: | OpenAIRE |
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