Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media
| Autor: | Patricia A. Schachern, Norma de Oliveira Penido, Michael M. Paparella, Sebahattin Cureoglu, Rafael da Costa Monsanto, Mio Uchiyama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Perforation (oil well) Scarpa's ganglion Vestibular Nerve Article 03 medical and health sciences 0302 clinical medicine Temporal bone otorhinolaryngologic diseases medicine Humans 030223 otorhinolaryngology Tympanosclerosis Neurons Vestibular system business.industry Temporal Bone Cholesteatoma General Medicine medicine.disease Cochlea Ganglion Otitis Media medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Middle ear sense organs Spiral Ganglion business |
| Zdroj: | Eur Arch Otorhinolaryngol |
| ISSN: | 1434-4726 0937-4477 |
| Popis: | PURPOSE: In this study, we aimed to determine whether or not COM leads to loss of spiral and Scarpa ganglion neurons. METHODS: From the human temporal bone (HTB) collection at the University of Minnesota we selected human temporal bones with COM, defined as the presence of clinically intractable tissue abnormalities in the middle ear (cholesteatoma, perforation of the eardrum, granulation tissue, fibrosis, tympanosclerosis, and cholesterol granuloma). We also selected HTBs from donors with no ear diseases as controls. We quantitatively analyzed the number of spiral and Scarpa ganglion cells and compared the results obtained in the control and study groups. RESULTS: In both COM and control groups, we observed a significant negative correlation between age and number of both spiral (R= −0.632; P0.05). CONCLUSIONS AND RELEVANCE: Our results did not demonstrate significant loss of cochlear or vestibular peripheral ganglion neuron loss in HTBs with COM as compared with controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink