A new gluco indole alkaloid, 3, 4-dehydro-5-carboxystrictosidine, from Peruvian Uña de Gato (Uncaria tomentosa)
| Autor: | Shin-ichiro Sakai, Masashi Yokoya, Ken-ichiro Hashimoto, Mariko Kitajima, Hiromitsu Takayama, Norio Aimi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Indole test Indoles biology Indole alkaloid Molecular Structure Stereochemistry Alkaloid Chemical structure Spectrum Analysis Glycoside Rubiaceae General Chemistry General Medicine Pharmacognosy biology.organism_classification chemistry.chemical_compound Alkaloids chemistry Drug Discovery Uncaria tomentosa Methylene |
| Zdroj: | Chemicalpharmaceutical bulletin. 48(10) |
| ISSN: | 0009-2363 |
| Popis: | A new gluco indole alkaloid, 3,4-dehydro-5-carboxystrictosidine, was obtained from Peruvian Uña de Gato (Cat's Claw, original plant: Uncaria tomentosa) together with two known gluco indole alkaloids. This compound was the first example of isolation of a gluco monoterpenoid indole alkaloid having a 3,4-dihydro-beta-carboline ring system from nature. A characteristic feature of the compound was the quick replacement of the methylene hydrogens on C-14 with deuterium that was observed when it was dissolved in CD3OD. We demonstrated a similar proton-deuterium exchange on a model compound, 1-methyl-3,4-dihydro-gamma-carboline, in CD3OD solution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|