Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results
| Autor: | Soumarová R, Barbara Jezková, Hana Vojkovská, Zuzana Šeneklová, Ivana Horová, Horová H, Marie Budíková, Jana Růzicková |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Population Breast Neoplasms Disease-Free Survival Medical Records Breast cancer Phyllodes Tumor medicine Humans education Aged Czech Republic Retrospective Studies education.field_of_study business.industry Standard treatment Obstetrics and Gynecology Phyllodes tumor Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Surgery Radiation therapy Female Neoplasm Recurrence Local business Mastectomy |
| Zdroj: | Archives of Gynecology and Obstetrics. 269:278-281 |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-003-0593-7 |
| Popis: | Mastectomy without axillary dissection should be the standard treatment in patients with malignant form of cystosarcoma phyllodes. The role of postoperative radiotherapy and chemotherapy remains to be fully established. We evaluate treatment results in a group of patients with cystosarcoma phyllodes (CP) treated at our Institute. In this report we analyze treatment outcome in 25 patients with malignant cystosarcoma phyllodes treated at Masaryk Memorial Cancer Institute between 1970 and 1995. Mean tumor size was 10 cm in diameter. All patients underwent surgery. Subsequently, 17 patients (68%) received radiotherapy on the breast or chest wall. Median follow-up was 139.5 months. Local recurrence was observed in 16% of all patients and all patients with local recurrence died. Time to local relapse after surgery was 4–11 months. Distant metastases occurred in 5 patients. All patients with local recurrence had distant metastases. Dissemination occurred 3–19 months after local recurrence. Five-year survival of all patients was 80%. A specific protocol for the treatment of cystosarcoma phyllodes is missing, probably due to rarity of the disease. The treatment of local recurrent disease remains unsuccessful in most CP patients. We recommend postoperative irradiation on the chest wall in patients with malignant form of CP, because adjuvant radiotherapy decreased the incidence of local relapse in our group of patients. |
| Databáze: | OpenAIRE |
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