Heart-rate-variability (HRV), predicts outcomes in COVID-19
| Autor: | Yori Gidron, Moshe Farchi, F. Jeroen Vogelaar, Dennis G. Barten, Maud T.A. Strous, Maartje B A Mol, Frits H.M. van Osch, Norbert A. Foudraine |
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| Přispěvatelé: | Epidemiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
STIMULATION Viral Diseases Pulmonology Cardiovascular Medicine law.invention Electrocardiography Medical Conditions Heart Rate law Medicine and Health Sciences Heart rate variability Immune Response Aged 80 and over Multidisciplinary Age Factors Heart Middle Aged Prognosis Intensive care unit CANCER Hospitals Intensive Care Units Infectious Diseases Bioassays and Physiological Analysis Treatment Outcome Cardiovascular Diseases Cardiology Medicine Female medicine.symptom Research Article circulatory and respiratory physiology Bradycardia medicine.medical_specialty Science Immunology Research and Analysis Methods Asymptomatic Respiratory Disorders Signs and Symptoms Diagnostic Medicine Internal medicine Heart rate medicine Humans Heart Atria VAGAL NERVE ACTIVITY Aged Retrospective Studies Inflammation VAGUS NERVE SARS-CoV-2 Surrogate endpoint business.industry Myocardium Electrophysiological Techniques Biology and Life Sciences COVID-19 Covid 19 Retrospective cohort study Vagus nerve Health Care Health Care Facilities Respiratory Infections Electrocardiography Ambulatory Cardiac Electrophysiology Clinical Medicine business |
| Zdroj: | PLOS ONE, 16(10):0258841. Public Library of Science PLoS ONE, Vol 16, Iss 10, p e0258841 (2021) PLoS ONE, Vol 16, Iss 10 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0258841 |
| Popis: | Background Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe illness and death. Whilst previous studies have clarified these and several other aspects of COVID-19, one of the ongoing challenges regarding COVID-19 is to determine which patients are at risk of adverse outcomes of COVID-19 infection. It is hypothesized that this is the result of insufficient inhibition of the immune response, with the vagus nerve being an important neuro-immuno-modulator of inflammation. Vagus nerve activity can be non-invasively indexed by heart-rate-variability (HRV). Therefore, we aimed to assess the prognostic value of HRV, as a surrogate marker for vagus nerve activity, in predicting mortality and intensive care unit (ICU) referral, in patients hospitalized with COVID-19. Methods A retrospective cohort study including all consecutive patients (n = 271) diagnosed and hospitalized with COVID-19 between March 2020 and May 2020, without a history of cardiac arrhythmias (including atrial and ventricular premature contractions), pacemaker, or current bradycardia (heart rate 110 bpm). HRV was based on one 10s ECG recorded at admission. 3-week survival and ICU referral were examined. Results HRV indexed as standard deviation of normal to normal heartbeat intervals (SDNN) predicted survival (H.R. = 0.53 95%CI: 0.31–0.92). This protective role was observed only in patients aged 70 years and older, not in younger patients. HRV below median value also predicted ICU referral within the first week of hospitalization (H.R = 0.51, 95%CI: 0.29–0.90, P = 0.021). Conclusion Higher HRV predicts greater chances of survival, especially in patients aged 70 years and older with COVID-19, independent of major prognostic factors. Low HRV predicts ICU indication and admission in the first week after hospitalization. |
| Databáze: | OpenAIRE |
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