Activated Protein C Resistance (APCR) and Placental Fibrin Deposition

Autor: Mark Lyons, Majella Maher, S. Sedano, Margaret Murray, G. Mortimer, Brendan Cleary, G Gaffney
Rok vydání: 2008
Předmět:
Zdroj: Placenta. 29:833-837
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2008.06.012
Popis: Activated protein C resistance (APCR) results in an ineffective anticoagulant response leading to an increased risk of thrombosis, particularly during pregnancy. Adverse pregnancy outcomes including pre-eclampsia (PET), intrauterine growth restriction (IUGR), recurrent miscarriage and placental abruption have been linked with thrombotic lesions compromising the utero-placental circulation. Using histological staining including Martius Scarlet Blue (MSB) and Haematoxylin and Eosin (H&E) and microscopy, we studied placental fibrin deposition and histological abnormalities in subjects ( n = 23) with APCR (APCR group), based on a ratio of less than or equal to 2.1 s with the Coatest ® classic test and subjects ( n = 11) with an APC ratio in the normal range, greater than 2.1 s (APCN group). Fibrin deposition was significantly higher (3.3-fold) in the APCR group compared to the APCN group. An inverse correlation between APC ratio and placental fibrin deposition was determined for the study group. Histological abnormalities were more than 2-fold higher in the APCR group compared to the APCN group. Molecular screening identified common thrombophilic mutations, FVL and FII-G20210A in the APCR group but not in the APCN group.
Databáze: OpenAIRE
Externí odkaz: