Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti- inflammatory drugs and opioids
| Autor: | Dalia Vađunec, Jelena Kurija, Dragan Primorac, Sara Šipicki, Ryan A. Gregg, Ivan Mikula, Lidija Bach-Rojecky, Katarina Žunić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacogenomic Variants medicine.drug_class Inadequate Pain Relief Analgesic Pain Coding (therapy) Pharmacogenomic Testing BIOMEDICINA I ZDRAVSTVO. Farmacija 030105 genetics & heredity Bioinformatics Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Pain Management Medicine Precision Medicine genes pharmacogenetics Pharmacology nonsteroidal anti-inflammatory drugs Analgesics Nonsteroidal epigenetics business.industry BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences Anti-Inflammatory Agents Non-Steroidal opioids toxicity General Medicine Pain management BIOMEDICINE AND HEALTHCARE. Pharmacy Analgesics Opioid analgesic effect pain treatment side effects chemistry 030220 oncology & carcinogenesis Molecular Medicine BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti business Pharmacogenetics |
| Zdroj: | Personalized Medicine Volume 16 Issue 2 |
| ISSN: | 1741-0541 |
| Popis: | Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti-inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Allelic variants in genes coding for target proteins, transporters and enzymes, which govern analgesic drugs action and their fate in the organism, might explain inter-individual variability in pain severity and in drug-induced pain relief and toxicities. Additionally, it seems that epigenetic changes contribute to the highly variable response to pain treatment. Therefore, pharmacogenomic testing might be a valuable tool for personalization of pain treatment, with a multidisciplinary team approach involved. |
| Databáze: | OpenAIRE |
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