Alpha‐ and beta‐synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia
| Autor: | Lucia R. Wolgast, Robert W. Maitta, Hailing Zhang, Jaya Sunkara, John G. Pizzolo, K. H. Ramesh, Jerald Z. Gong, Howard Ratech, Qing Wang, Joseph Albanese, Pritish K. Bhattacharyya, Linda A. Cannizzaro |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty animal diseases Diagnosis Differential Acute megakaryoblastic leukemia beta-Synuclein gamma-Synuclein Bone Marrow Leukemia Megakaryoblastic Acute Cell Line Tumor hemic and lymphatic diseases Internal medicine mental disorders medicine Humans Child Early Detection of Cancer Myeloproliferative neoplasm Aged Aged 80 and over Leukemia Hematology Lewy body business.industry Acute erythroid leukemia Myeloid leukemia Middle Aged medicine.disease Neoplasm Proteins nervous system diseases Haematopoiesis medicine.anatomical_structure nervous system Child Preschool Megakaryoblast Immunology alpha-Synuclein Female Leukemia Erythroblastic Acute business Biomarkers Megakaryocyte-Erythroid Progenitor Cells |
| Zdroj: | American Journal of Hematology. 86:230-234 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.21932 |
| Popis: | α-Synuclein is a key component of the Lewy body, a large globular protein complex that forms in the nervous system of patients with Parkinson disease and other dementias [1-3]. Since α-synuclein also occurs in megakaryocytic and erythroid lineages [4-7], we wondered what role synucleins had in the hematopoietic system. Therefore, we studied the expression of α-, β-, and γ-synucleins in a comprehensive panel of patient bone marrows and leukemic cell lines. We observed under expression of α-synuclein in the megakaryocytes of myeloproliferative neoplasm (MPN), but not normal reactive marrow (NRM) or myelodysplastic syndrome (MDS). Conversely, we observed over expression of β-synuclein in the blasts of megakaryoblastic leukemias (MegL), but not acute myeloid leukemia (AML) or erythroleukemia (EryL), suggesting that α- and β-synucleins could be useful adjunct markers for the early detection of MDS and the differential diagnosis of EryL and MegL from other AMLs. |
| Databáze: | OpenAIRE |
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