Mindfulness-based cognitive therapy for patients with chronic, treatment-resistant depression: A pragmatic randomized controlled trial
| Autor: | Anne E. M. Speckens, Mira B. Cladder-Micus, Jan Spijker, Eni S. Becker, A. Rogier T. Donders, Janna N. Vrijsen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 050103 clinical psychology medicine.medical_specialty mindfulness Mindfulness medicine.medical_treatment Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Poison control law.invention Experimental Psychopathology and Treatment Depressive Disorder Treatment-Resistant 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center depressive disorder Randomized controlled trial Quality of life law Internal medicine Outpatients Humans Medicine 0501 psychology and cognitive sciences Research Articles Mindfulness-based cognitive therapy Cognitive Behavioral Therapy Depression business.industry 05 social sciences Other Research Radboud Institute for Health Sciences [Radboudumc 0] treatment‐resistant depression Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Treatment Outcome quality of life randomized controlled trial Rumination Cognitive therapy Female medicine.symptom business Treatment-resistant depression Research Article |
| Zdroj: | Depression and Anxiety, 35, 10, pp. 914-924 Depression and Anxiety, 35, 914-924 Depression and Anxiety |
| ISSN: | 1091-4269 |
| Popis: | Contains fulltext : 195861pub.pdf (Publisher’s version ) (Open Access) Background: Chronic and treatment-resistant depressions pose serious problems in mental health care. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for remitted and currently depressed patients. It is, however, unknown whether MBCT is effective for chronic, treatment-resistant depressed patients. Method: A pragmatic, multicenter, randomized-controlled trial was conducted comparing treatment-as-usual (TAU) with MBCT + TAU in 106 chronically depressed outpatients who previously received pharmacotherapy (>= 4 weeks) and psychological treatment (>= 10 sessions). Results: Based on the intention-to-treat (ITT) analysis, participants in the MBCT + TAU condition did not have significantly fewer depressive symptoms than those in the TAU condition (-3.23 [-6.99 to 0.54], d = 0.35, P = 0.09) at posttreatment. However, compared to TAU, the MBCT + TAU group reported significantly higher remission rates (X2(2) = 4.25, phi = 0.22, P = 0.04), lower levels of rumination (-3.85 [-7.55 to -0.15], d = 0.39, P = 0.04), a higher quality of life (4.42 [0.03–8.81], d = 0.42, P = 0.048), more mindfulness skills (11.25 [6.09-16.40], d = 0.73, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|