Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease
| Autor: | Efstratios Stratikos, José A. López de Castro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Immunology Intracellular Space Endoplasmic Reticulum Aminopeptidases Structure-Activity Relationship 03 medical and health sciences Enzyme activator 0302 clinical medicine Immune system MHC class I Animals Humans Immunology and Allergy Cytotoxic T cell Molecular Targeted Therapy Regulation of gene expression Antigen Presentation biology Antigen processing Histocompatibility Antigens Class I Genetic Variation General Medicine Endoplasmic reticulum aminopeptidase 2 Cell biology Enzyme Activation 030104 developmental biology Gene Expression Regulation biology.protein Disease Susceptibility Peptides Intracellular Protein Binding 030215 immunology |
| Zdroj: | Human Immunology. 80:310-317 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2018.11.001 |
| Popis: | Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) is an intracellular enzyme localized in the ER that has been shown to play roles in the generation of peptides that serve as ligands for MHC class I (MHC-1) molecules. Although ERAP2 has been primarily described as an accessory and complementary enzyme to the homologous ERAP1, several lines of evidence during the last few years suggest that it can play distinct and important roles in processing antigenic peptides and influencing cellular cytotoxic immune responses. Such emerging evidence has been shaping ERAP2 as a potentially tractable target for regulating select autoimmune and anti-cancer responses for therapeutic purposes. Here, we review the state-of-the-art knowledge on the role of ERAP2 in antigen processing, its structure and molecular mechanism, influence on shaping MHC-I-bound immunopeptidomes and its involvement in disease pathogenesis. |
| Databáze: | OpenAIRE |
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