Encapsulated porcine islet transplantation: an evolving therapy for the treatment of Type I diabetes
| Autor: | Christopher G. Thanos, R B Elliott |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Graft Rejection
Pancreas Artificial Swine Xenotransplantation medicine.medical_treatment Transplantation Heterologous Clinical Biochemistry Islets of Langerhans Transplantation Immune system Diabetes mellitus Drug Discovery medicine Animals Humans Pharmacology geography geography.geographical_feature_category business.industry Porcine islets Endogenous Retroviruses medicine.disease Islet Specific Pathogen-Free Organisms Transplantation Diabetes Mellitus Type 1 medicine.anatomical_structure Immunology Type i diabetes business Pancreas |
| Zdroj: | Expert Opinion on Biological Therapy. 9:29-44 |
| ISSN: | 1744-7682 1471-2598 |
| DOI: | 10.1517/14712590802630666 |
| Popis: | Allogeneic tissue-based therapies for Type I diabetes have demonstrated efficacy but are limited due to tissue-sourcing constraints, as the number of patients exceeds that of tissue donors. Porcine islets derived from designated pathogen-free sources could be an alternative, particularly if delivered in a way that evades the host immune system's rejection.This review focuses on approaches designed to protect xenogeneic islets from immune rejection by provision of perm-selective barriers.Designated pathogen-free herds could provide a supply of wild-type porcine islets that are well tolerated when administered in a suitable protective delivery vehicle. Such barrier systems have enabled amelioration of diabetes in a variety of animal models and preliminary evidence suggests that similar results could be attained in humans.With advances in biomaterial design, source tissue selection, and the evolution of critical cell processing techniques, contemporary encapsulated porcine islet therapies offer a new level of clinical promise. |
| Databáze: | OpenAIRE |
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