Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditions
| Autor: | Daniela Massihnia, Marta Castiglia, Federica Grisafi, Antonio Russo, Anna Barbara Di Stefano, Francesca Toia, Luigi Montesano, Adriana Cordova, Francesco Moschella |
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| Přispěvatelé: | Di Stefano AB, Massihnia D, Grisafi F, Castiglia M, Toia F, Montesano L, Russo A, Moschella F, Cordova A. |
| Rok vydání: | 2018 |
| Předmět: |
Cell type
Adipose stem cell Histology Stromal cell Settore MED/06 - Oncologia Medica Angiogenesis Settore MED/19 - Chirurgia Plastica Adipose tissue Neovascularization Physiologic Biology Pathology and Forensic Medicine Neovascularization Endothelial cell Neoplasms microRNA medicine Animals Humans Obesity Stem Cells Endothelial Cells Cell Biology General Medicine Cell biology Angiogenesi MicroRNAs Adipose Tissue miRNAs medicine.symptom Stem cell Adult stem cell |
| Zdroj: | European journal of cell biology. 98(2-4) |
| ISSN: | 1618-1298 |
| Popis: | Angiogenesis is a crucial process for the maintenance of normal tissue physiology and it is involved in tissue remodeling and regeneration. This process is essential for adipose tissue maintenance. The adipose tissue is composed by different cell types including stromal vascular cells as well as adipose stem cells (ASCs). In particular, ASCs are multipotent somatic stem cells that are able to differentiate and secrete several growth factors; they are recently emerging as a new cell reservoir for novel therapies and strategies in many diseases. Several studies suggest that ASCs have peculiar properties and participate in different disease-related processes such as angiogenesis. Furthermore, pathological expansion of adipose tissue brings to hypoxia, a major condition of unhealthy angiogenesis. Recent evidences have shown that microRNAs (miRNAs) play a crucial role also on ASCs as they take part in stemness maintenance, proliferation, and differentiation. It has been suggested that some miRNAs (MIR126, MIR31, MIR221 MIR222, MIR17-92 cluster, MIR30, MIR100 and MIR486) are directly involved in the angiogenic process by controlling multiple genes involved in this pathway. With the present review, we aim at providing an updated summary of the importance of adipose tissue under physiological and pathological conditions and of its relationship with neovascularization process. In particular, we report an overview of the most important miRNAs involved in angiogenesis focusing on ASCs. Hopefully the data presented will bring benefit in developing new therapeutic strategies. |
| Databáze: | OpenAIRE |
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