Frequency of brain MRI abnormalities in neuromyelitis optica spectrum disorder at presentation: A cohort of Latin American patients
| Autor: | Mónica Perassolo, Edgar Carnero Contentti, V. D. Marques, Verónica Tkachuk, Omaira Molina, Carolina Lavigne Moreira, Amilton Antunes Barreira, Edson Chiganer, Elizabeth Armas, Ibis Soto de Castillo, José Luis Di Pace, Alejandro Caride, Javier Pablo Hryb, A. Soto, Carmen Lessa, Camila de Aquino Cruz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Argentina Optic chiasm Corpus callosum Asymptomatic White matter Young Adult 03 medical and health sciences 0302 clinical medicine Cerebellum medicine Humans 030212 general & internal medicine Autoantibodies Retrospective Studies Aquaporin 4 Neuromyelitis optica medicine.diagnostic_test business.industry Multiple sclerosis Neuromyelitis Optica Brain Magnetic resonance imaging General Medicine Middle Aged Venezuela medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Corticospinal tract Female Neurology (clinical) medicine.symptom business Brazil 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Multiple Sclerosis and Related Disorders. 19:73-78 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2017.11.004 |
| Popis: | Background Brain magnetic resonance imaging (BMRI) lesions were classically not reported in neuromyelitis optica (NMO). However, BMRI lesions are not uncommon in NMO spectrum disorder (NMOSD) patients. Objective To report BMRI characteristic abnormalities (location and configuration) in NMOSD patients at presentation. Methods Medical records and BMRI characteristics of 79 patients with NMOSD (during the first documented attack) in Argentina, Brazil and Venezuela were reviewed retrospectively. Results BMRI abnormalities were observed in 81.02% of NMOSD patients at presentation. Forty-two patients (53.1%) showed typical-NMOSD abnormalities. We found BMRI abnormalities at presentation in the brainstem/cerebellum (n = 26; 32.9%), optic chiasm (n = 16; 20.2%), area postrema (n = 13; 16.4%), thalamus/hypothalamus (n = 11; 13.9%), corpus callosum (n = 11; 13.9%), periependymal-third ventricle (n = 9; 11.3%), corticospinal tract (n = 7; 8.8%), hemispheric white matter (n = 1; 1.2%) and nonspecific areas (n = 49; 62.03%). Asymptomatic BMRI lesions were more common. The frequency of brain MRI abnormalities did not differ between patients who were positive and negative for aquaporin 4 antibodies at presentation. Conclusion Typical brain MRI abnormalities are frequent in NMOSD at disease onset. |
| Databáze: | OpenAIRE |
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