gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression
| Autor: | Darius Matusevicius, Piotr P. Murzenok, Mark S. Freedman |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Chemokine T cell Receptors Antigen T-Cell alpha-beta T-Lymphocytes Immunology medicine.disease_cause CXCR3 CCL5 Autoimmunity Chemokine receptor Multiple Sclerosis Relapsing-Remitting medicine Immunology and Allergy Humans Chemokine CCL5 biology T-cell receptor Receptors Antigen T-Cell gamma-delta T lymphocyte Middle Aged Multiple Sclerosis Chronic Progressive Flow Cytometry Chemokine CXCL10 medicine.anatomical_structure biology.protein Female Receptors Chemokine Chemokines |
| Zdroj: | Clinical immunology (Orlando, Fla.). 103(3 Pt 1) |
| ISSN: | 1521-6616 |
| Popis: | gamma/delta T cells are enriched in multiple sclerosis (MS) brain lesions and have been postulated to contribute to the pathogenesis of the disease. Increased expression of the chemokine receptors CCR5 and CXCR3 on T cells and raised amounts of the chemokines RANTES and IP-10 have been noted in the CSF and brain tissue of MS patients, but the contribution of gamma delta T cells to these increases is unknown. We therefore compared intracellular RANTES and IP-10 production as well as CCR5, CXCR3, and CXCR1 expression by gamma delta T cells derived from the blood and CSF of patients with MS and healthy controls (HC). We observed higher RANTES production by MS gamma delta than by alpha beta T cell lines. Most of the MS as well as the HC gamma delta and alpha beta T cell lines expressed CXCR3, while expression of CXCR1 was low. Interestingly, MS gamma delta T cell lines, compared to lines from HC, expressed lower levels of CCR5. Furthermore, CSF-derived gamma delta T cells had even lower CCR5 expression than blood-derived ones. The higher RANTES production by MS gamma delta T cell lines, together with a lower expression of CCR5, may reflect an autoregulatory loop, caused by an increased production of its ligands (RANTES, MIP-1 alpha, and MIP-1 beta) or due to other pro-inflammatory cytokines. Alternatively, we show that lower CCR5 expression could also reflect the result of repeated in vivo stimulation of gamma delta T cells by autoantigens. |
| Databáze: | OpenAIRE |
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