Relative effects of direct spread, lymph node metastasis and venous invasion in relation to blood borne distant metastasis present at the time of resection of colorectal cancer
| Autor: | Owen F. Dent, Charles Chan, Matthew J. F. X. Rickard, R. C. Newland, Anil Keshava, Michael Suen, Pierre H. Chapuis, Kyoung Ho Lee, Peter Stewart |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Colorectal cancer Logistic regression Gastroenterology Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Aged Neoplasm Staging business.industry Cancer Odds ratio medicine.disease Confidence interval Dissection 030104 developmental biology Lymphatic system Cross-Sectional Studies Logistic Models 030220 oncology & carcinogenesis Lymphatic Metastasis Female Lymph Nodes business Colorectal Neoplasms |
| Zdroj: | Pathology. 52(6) |
| ISSN: | 1465-3931 |
| Popis: | Conventionally, lymphatic spread is regarded as the principal mechanism by which haematogenous metastasis occurs in colorectal cancer. The aim of this cross sectional study was to determine the relative strengths of direct tumour spread, the presence of lymph node metastasis and histologically demonstrated venous invasion as drivers of haematogenous metastasis diagnosed at the time of resection of colorectal cancer. The data were drawn from a hospital database of consecutive bowel cancer resections between 1995 and 2017 inclusive. The presence of haematogenous metastasis was determined at the time of surgery by imaging or other investigations or operative findings. Where possible, histological confirmation was obtained. Specimen dissection and reporting followed a standardised procedure. Tumour staging was according to the 7th edition of the UICC/AJCC pTNM system. Analysis was by multivariable logistic regression. After exclusions 3133 patients remained, among whom 380 (12.1%) had one or more haematogenous metastases. In bivariate analyses, the frequency of haematogenous metastasis was directly associated with increasing T status (p |
| Databáze: | OpenAIRE |
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