Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Autor:	Imke A. B. Pijpers, Fenghua Meng, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen
Přispěvatelé:	Bio-Organic Chemistry, ICMS Core, ICMS Business Operations
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Materials science Polymers and Plastics Organic Chemistry Nanoparticle Bioengineering Polymer Biochemistry Polymer engineering Solvent chemistry.chemical_compound chemistry Chemical engineering Amphiphile Polymersome Copolymer Tetrahydrofuran
Zdroj:	Polymer Chemistry, 11(2):2, 275-280. Royal Society of Chemistry
ISSN:	1759-9962 1759-9954
Popis:	The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d2b7aca56af3f50f6b7ef35f0f67d https://research.tue.nl/en/publications/b422f5dc-8970-4c81-9318-f1cde4fd3b3d Zobrazit plný text záznamu