Interferon gamma release assays for detection of latent Mycobacterium tuberculosis in older Hispanic people
| Autor: | Mateo Joya-Ayala, Francisco Mora-Guzmán, Doris Ayala, Alejandro Villafañez, Génesis P. Aguillón-Durán, Ana Paulina Quirino-Cerrillo, Larry S. Schlesinger, Jordi B. Torrelles, Blanca I. Restrepo, Eder Ledezma-Campos, Eminé Rodríguez-Reyna, Joanne Turner, Julia M. Scordo |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty diagnosis Concordance Infectious and parasitic diseases RC109-216 Article Mycobacterium tuberculosis older people Age groups Latent Tuberculosis Internal medicine medicine Humans Interferon gamma Aged Aged 80 and over IGRA biology business.industry Tuberculin Test Latent TB infection General Medicine Hispanic or Latino biology.organism_classification Infectious Diseases Cross-Sectional Studies Older people business Kappa Interferon-gamma Release Tests medicine.drug |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases International Journal of Infectious Diseases, Vol 111, Iss, Pp 85-91 (2021) |
| ISSN: | 1878-3511 |
| Popis: | SUMMARY: Background: Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection in older Hispanic recent TB contacts (ReC) or community controls (CoC). Methods: Cross-sectional assessment of LTBI with T-SPOT.TB and/or QuantiFERON-Gold in-tube or –Plus assay in older (≥60 years) and adult (18–50 years) Hispanic people. Results: We enrolled 193 CoC (119 adults, 74 older persons) and 459 ReC (361 adults, 98 older persons). LTBI positivity increased with age in CoC (19%–59%, P |
| Databáze: | OpenAIRE |
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