Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces
| Autor: | Tibor Nanasi, István Ulbert, Kinga Tóth, Patrick Ruther, Vivien Csikós, Christian Böhler, Maria Asplund, Domonkos Horváth, Richárd Fiáth, F. Pothof, Katharina T. Hofer |
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| Rok vydání: | 2018 |
| Předmět: |
Neurons
0301 basic medicine Materials science Focus (geometry) Biocompatibility Polymers Biomedical Engineering Brain Biocompatible Materials Electroencephalography Local field potential Rats 03 medical and health sciences Microelectrode Electrophysiology 030104 developmental biology 0302 clinical medicine Animals Humans Temporal change Epileptic foci Microelectrodes 030217 neurology & neurosurgery Biomedical engineering Brain–computer interface |
| Zdroj: | Biomedical Engineering / Biomedizinische Technik. 63:301-315 |
| ISSN: | 1862-278X 0013-5585 |
| DOI: | 10.1515/bmt-2017-0154 |
| Popis: | Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6–12 macro- or microelectrodes), limited spatial resolution (0.5–1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the probe track. Our data on biocompatibility presented here and in vivo experiments in non-human primates provide a strong indication that this type of neural probe can be applied in stereo-electroencephalography recordings of up to 2 weeks in humans targeting the localization of epileptic foci providing an increased spatial resolution and the ability to monitor local field potentials and neuronal spiking activity. |
| Databáze: | OpenAIRE |
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