Carnitine prevents cyclic GMP-induced inhibition of peroxisomal enzyme activities

Autor:	Gursev S. Dhaunsi, Pinar Ozand, Allie Moosa, Mazen Al-Essa
Rok vydání:	2004
Předmět:	biology Clinical Biochemistry Cell Biology General Medicine Fibroblasts Peroxisome Catalase medicine.disease Biochemistry Carnitine Acyltransferase Peroxisomal disorder Peroxisomes medicine biology.protein Humans Microbody Acyl-CoA oxidase Cyclic GMP Beta oxidation Cells Cultured medicine.drug
Zdroj:	Cell Biochemistry and Function. 22:365-371
ISSN:	1099-0844 0263-6484
Popis:	Peroxisomes, also termed as microbodies, are now known to carry out several specialized metabolic activities that are vital to cellular function. A defect in peroxisomal function leads to development of a fatal human disease, and a number of peroxisomal disorders are now linked to inherited peroxisomal enzyme abnormalities. Peroxisomal enzyme activities are also altered during pathophysiological conditions through various endogenously produced bio-molecules such as nitric oxide (NO). NO produced by cytokines or NO-donors is known to modulate peroxisomal functions, and these effects of NO are mediated through cGMP. We are reporting for the first time that L-carnitine (1–5 mm) prevents cGMP-mediated impairment of peroxisomal enzyme activities. Cyclic GMP (250–1000 μM) significantly inhibited (p
Databáze:	OpenAIRE
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