Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer
| Autor: | Yuji Sagara, Tomayoshi Hayashi, Shigeru Kanda, Takahisa Iwata, Hideki Sakai, Yasuyoshi Miyata, Hiroshi Kanetake |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Bladder cancer Oncogene business.industry Cancer General Medicine Articles medicine.disease medicine.disease_cause urologic and male genital diseases Molecular medicine female genital diseases and pregnancy complications Metastasis Immunology and Microbiology (miscellaneous) Internal medicine Cancer cell medicine Immunohistochemistry business Carcinogenesis |
| Zdroj: | Experimental and therapeutic medicine. 1(1) |
| ISSN: | 1792-0981 |
| Popis: | Various therapeutic modalities are available for treatment of bladder cancer, and their effectiveness and patient outcome often depend on cancer cell invasiveness. However, the mechanisms underlying the early steps of bladder cancer cell invasion remain unknown. This study aimed to clarify the relationships between S100A4 expression and bladder cancer invasion of surrounding muscles, prognosis and expression of matrix metalloproteinase (MMP)-14 in patients with organ-confined bladder cancer. S100A4 and MMP-14 expression was analyzed in 85 cases of organ-confined (pTa, pT1 and pT2) bladder cancer using immunohistochemical technique. The expression levels were compared among the pTa, pT1 and pT2 tumors. In addition, the predictive values of S100A4 or MMP-14 expression for muscle invasion, metastasis and survival were investigated, as was the possible correlation between the expression of the two proteins. The proportion of S100A4-positive cancer cells in pT2 tumors (53%) was significantly higher (p |
| Databáze: | OpenAIRE |
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