The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults
| Autor: | Gwang Seok Kim, Hyun Yoon, Ae Eun Moon, Sung Gil Kim, Jun Ho Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
estimated glomerular filtration rate National Health and Nutrition Examination Survey Clinical Biochemistry 030232 urology & nephrology Urology Medicine (miscellaneous) Renal function vitamin D 030204 cardiovascular system & hematology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine urine microalbumin/creatinine ratio medicine Vitamin D and neurology Creatinine Nutrition and Dietetics Urine microalbumin/creatinine ratio business.industry Odds ratio medicine.disease Normal group chemistry Original Article business |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.17-69 |
| Popis: | The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) were analyzed. After adjusting for the related variables (except age), the odds ratios (ORs) of vitamin D deficiency with the normal group as a reference were significantly higher in the decreased eGFR plus elevated uACR group [3.089 (95% CI, 1.722-5.544)], but not in the elevated uACR [1.247 (95% CI, 0.986-1.577)] and decreased eGFR group [1.303 (95% CI, 0.789-2.152)]. However, when further adjusting for age, the ORs of vitamin D deficiency with the normal group as a reference were significantly higher in the elevated uACR group [1.312 (95% CI, 1.035-1.662)], decreased eGFR group [1.761 (95% CI, 1.062-2.919)] and the decreased eGFR plus elevated uACR group [3.549 (95% CI, 1.975-6.365)]. In conclusion, vitamin D deficiency was positively associated with the elevated uACR and decreased eGFR. In addition, vitamin D level decreased greatly when decreased eGFR and elevated uACR appeared simultaneously. |
| Databáze: | OpenAIRE |
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