Risk factors for concurrent bacteremia in adult patients with dengue
| Autor: | Yee Sin Leo, Ming S. Yeang, David C. Lye, Ee-Ling Ng, Tun-Linn Thein |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Microbiology (medical) medicine.medical_specialty Multivariate analysis Adolescent 030106 microbiology 030231 tropical medicine lcsh:QR1-502 Bacteremia Severity lcsh:Microbiology Dengue fever Dengue 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Internal medicine Immunology and Microbiology(all) medicine Humans Immunology and Allergy Mortality Young adult Intensive care medicine Survival analysis Aged Retrospective Studies Aged 80 and over Singapore General Immunology and Microbiology business.industry Case-control study Retrospective cohort study General Medicine Middle Aged medicine.disease Survival Analysis Hospitals Infectious Diseases Case-Control Studies Concurrent bacteremia Female business Cohort study |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 50, Iss 3, Pp 314-320 (2017) |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2015.06.008 |
| Popis: | Background/Purpose Bacteremia in dengue may occur with common exposure to pathogens in association with severe organ impairment or severe dengue, which may result in death. Cohort studies identifying risk factors for concurrent bacteremia among patients with dengue are rare. Methods We conducted a retrospective case–control study of adult patients with dengue who were admitted to the Department of Infectious Diseases at Tan Tock Seng Hospital, Singapore from 2004 to 2008. For each case of dengue with concurrent bacteremia (within the first 72 hours of admission), we selected four controls without bacteremia, who were matched on year of infection and dengue confirmation method. Conditional logistic regression was performed to identify risk factors for concurrent bacteremia. Results Among 9,553 patients with dengue, 29 (0.3%) had bacteremia. Eighteen of these patients (62.1%) had concurrent bacteremia. The predominant bacteria were Staphylococcus aureus , one of which was a methicillin-resistant strain. Dengue shock syndrome occurred more frequently and hospital stay was longer among cases than among controls. Three cases did not survive, whereas none of the controls died. In multivariate analysis, being critically ill at hospital presentation was independently associated with 15 times the likelihood of a patient with dengue having concurrent bacteremia. Conclusion Concurrent bacteremia in adult patients with dengue is uncommon but presents atypically and results in more deaths and longer hospital stay. Given the associated mortality, collection of blood cultures and empiric antibiotic therapy may be considered in patients who are critically ill. |
| Databáze: | OpenAIRE |
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