Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug
| Autor: | Mille B. L. Kryger, Almar Postma, Benjamin M. Wohl, Natasha Hedemann, Carlos Guerrero-Sanchez, Anton A. A. Smith, Alexander N. Zelikin |
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| Rok vydání: | 2014 |
| Předmět: |
Drug
Magnetic Resonance Spectroscopy Macromolecular prodrugs Side effect media_common.quotation_subject Biomedical Engineering Pharmaceutical Science Pharmacology Nitric Oxide Antiviral Agents Cell Line Biomaterials Mice chemistry.chemical_compound Drug Discovery Ribavirin Animals Prodrugs media_common Macrophages Prodrug Molecular Weight chemistry Drug delivery Chromatography Gel |
| Zdroj: | Smith, A A A, Wohl, B M, Kryger, M B L, Hedemann, N, Guerrero-Sanchez, C, Postma, A & Zelikin, A N 2014, ' Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug ', Advanced Healthcare Materials, vol. 3, no. 9, pp. 1404-1407 . https://doi.org/10.1002/adhm.201300637 |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201300637 |
| Popis: | Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad-spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin. |
| Databáze: | OpenAIRE |
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