Treatment of cystoid macular edema in homozygous twins with glutathione synthetase deficiency and retinal dystrophy
| Autor: | R. Warrak, F. Matonti, O. Fakhoury, J. Conrath, B. Donnadieu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Retinal dystrophy Administration Oral Thiophenes Glutathione Synthase Macular Edema 03 medical and health sciences 0302 clinical medicine Dorzolamide Ophthalmology Retinal Dystrophies Diseases in Twins medicine Humans Child Amino Acid Metabolism Inborn Errors Macular edema Sulfonamides business.industry Glutathione synthetase deficiency medicine.disease Combined Modality Therapy eye diseases Discontinuation Acetazolamide Treatment modality 030221 ophthalmology & optometry Drug Therapy Combination sense organs Ophthalmic Solutions business 030217 neurology & neurosurgery After treatment medicine.drug |
| Zdroj: | Journal Français d'Ophtalmologie. 41:116-121 |
| ISSN: | 0181-5512 |
| DOI: | 10.1016/j.jfo.2017.08.010 |
| Popis: | Monozygotic twins with glutathione synthetase deficiency, progressive retinal dystrophy and cystoid macular edema were followed for foveal changes on optical coherence tomography under different treatment modalities. The purpose of the study is to show the effect of topical dorzolamide in conjunction with systemic acetazolamide in terms of decreasing macular edema in this specific disease. The results showed that systemic acetazolamide alone or in combination with topical dorzolamide decreased CME in both patients for a certain period of time. The result can be temporary sustained after treatment discontinuation. In conclusion, topical dorzolamide, in conjunction with systemic acetazolamide, could reduce cystoid macular edema in GSSD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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