Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?
| Autor: | Cedric Sottas, Paul-Henri Lambert, Jean Taguebue, Claude Lecoultre, Marie Kobela, Klara M. Posfay-Barbe, Stéphane Grillet, Claire-Anne Siegrist, Tetanye Ekoe |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Adolescent Tetanus Toxoid/*administration & dosage/*immunology Immunization Secondary Booster dose ddc:616.07 complex mixtures Immune system Immunity medicine Tetanus Toxoid Humans Child Immunization ddc:618 Antibodies Bacterial/immunology General Veterinary General Immunology and Microbiology biology Tetanus business.industry Public Health Environmental and Occupational Health Toxoid Antibody titer Infant medicine.disease Antibodies Bacterial Vaccination Infectious Diseases Immunology biology.protein Molecular Medicine Female Antibody business |
| Zdroj: | Vaccine, Vol. 28, No 27 (2010) pp. 4356-4361 |
| ISSN: | 1873-2518 0264-410X |
| Popis: | To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with aor =4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10UI/ml threshold. Response rates were slightly higher (62%) in children aged 10-11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection. |
| Databáze: | OpenAIRE |
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