| Popis: |
Helminthic infections are a major cause of morbidity and mortality worldwide and are prominent among the so called Neglected tropical diseases (NTDs). The NTDs include ‘Schistosomiasis and the soil transmitted helminthes’ (STH), a group of parasite whose life cycle usually depends on a period of development outside the human host, typically in moist, worm soil. An anthelmintic drug can act by causing paralysis of the worm, or by harmful its cuticle, which lead to partial absorption or rejection by immune mechanisms. Most of the existing synthetic anthelmintic drugs produce serious side effects. In order to reduce the harmful side effects of these synthetic anthelmintic drugs, it is significant for us to promote the studies of traditionally used anthelmintic plant based drugs. The methanol leaf extract of Crossandra infundibuliformis was prepared with distilled water by soxhlation method. The methanol leaf extract is used to evaluate the presence of phytoconstituents and anthelmintic activity. The anthelmintic activity was investigated on Pheritima posthuma (Indian earth worm). Anthelmintic activity was performed in three different concentrations such as 20 mg/ml, 50 mg/ml and 100 mg/ml. Albendazole (10 mg/ml) was used as reference standard drug whereas distilled water as control. Determination of paralysis time and death time of the worms were recorded. Methanol extract exhibited more noteworthy anthelmintic activity at the concentration of 100 mg/ml. The results reported in the present work shows evidence that the leaf extract of Crossandra infundibuliformis possess anthelmintic activity. KEYWORDS: Anthelmintic activity, Pheritima posthuma, Albendazole, Crossandra infundibuliformis. |
