Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma
| Autor: | Frédéric Bertrand, Nicodème Paul, Raoul Herbrecht, Leslie Muller, Luc-Matthieu Fornecker, Marie-Pierre Chenard, Raphael Carapito, Laurent Vallat, Sarah Cianférani, Angélique Pichot, Seiamak Bahram, Laurent Mauvieux, Christine Carapito |
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| Přispěvatelé: | Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Mathématique Avancée (IRMA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA) |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Proteomics 0301 basic medicine Hexokinase 3 Adolescent Quantitative proteomics lcsh:Medicine Biology Article Young Adult 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Tumor Microenvironment medicine [CHIM]Chemical Sciences Humans Metabolomics lcsh:Science education Aged Neoplasm Staging education.field_of_study Tumor microenvironment Multidisciplinary Gene Expression Profiling lcsh:R Computational Biology Genomics Middle Aged medicine.disease 3. Good health Lymphoma Gene expression profiling Gene Ontology Treatment Outcome 030104 developmental biology Drug Resistance Neoplasm Retreatment Cancer cell Cancer research Biomarker (medicine) Female lcsh:Q Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-018-37273-4⟩ |
| ISSN: | 2045-2322 |
| Popis: | The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic studies, the biological mechanisms underlying chemoresistance are still poorly understood. We conducted for the first time a large-scale differential multi-omics investigation on DLBCL patient’s samples in order to identify new biomarkers that could early identify patients at risk of R/R disease and to identify new targets that could determine chemorefractoriness. We compared a well-characterized cohort of R/R versus chemosensitive DLBCL patients by combining label-free quantitative proteomics and targeted RNA sequencing performed on the same tissues samples. The cross-section of both data levels allowed extracting a sub-list of 22 transcripts/proteins pairs whose expression levels significantly differed between the two groups of patients. In particular, we identified significant targets related to tumor metabolism (Hexokinase 3), microenvironment (IDO1, CXCL13), cancer cells proliferation, migration and invasion (S100 proteins) or BCR signaling pathway (CD79B). Overall, this study revealed several extremely promising biomarker candidates related to DLBCL chemorefractoriness and highlighted some new potential therapeutic drug targets. The complete datasets have been made publically available and should constitute a valuable resource for the future research. |
| Databáze: | OpenAIRE |
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