Gastrointestinal adverse reactions reduce the success rate of Helicobacter pylori eradication therapy: A multicenter prospective cohort study
| Autor: | Yasuhisa Sakata, Tetsuro Kajiwara, Atsuo Kuwahara, Yasuhiko Fujioka, Keiji Matsunaga, Motohiro Esaki, Kazuma Fujimoto, Keiichiro Hanada, Daisuke Yamaguchi, Kazutoshi Hashiguchi, Kazuto Taniguchi, Muneaki Matsuo, Shinichi Ogata, Ayako Takamori, Hiroyoshi Endo, Toshihiko Kakiuchi, Michihiro Sumino, Akira Watanabe, Kayoko Fukuda, Masaya Yoshimura, Eriko Muro, Koji Fukuyama, Hiroharu Kawakubo, Kohei Yamanouchi, Kentaroh Yamamoto, Takahiro Noda, Taro Akashi, Masumi Okuda, Ichiro Imamura |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain education Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Bristol stool scale Japan Internal medicine Clarithromycin Medicine Humans Prospective Studies Adverse effect Prospective cohort study Helicobacter pylori business.industry Incidence (epidemiology) Gastroenterology Amoxicillin Proton Pump Inhibitors General Medicine Discontinuation Anti-Bacterial Agents Diarrhea Infectious Diseases Treatment Outcome 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Drug Therapy Combination medicine.symptom business medicine.drug |
| Zdroj: | HelicobacterREFERENCES. 26(2) |
| ISSN: | 1523-5378 |
| Popis: | BACKGROUND The screening and treatment of Helicobacter pylori infection for all junior high students in Saga Prefecture, Japan, were started in 2016. The present study aims to evaluate the influence of adverse reactions on the success of the eradication therapy. METHODS From 2017 to 2019, 25,006 third-grade junior high school students were tested for urinary anti-H. pylori antibodies. Positive cases were confirmed by H. pylori stool antigen tests. Of the 531 students who were found to be H. pylori-positive, 390 (358 in first-line and 32 in second-line therapy) underwent eradication therapy, and 274 (242 in first-line and 32 in second-line) students actually completed a self-reported form to rate stool consistency (based on the Bristol Stool Scale), the maximum number of bowel movements, and abdominal symptoms during the 7 days of treatment. RESULTS Among the 274 students, the total of primary and secondary eradication success rates was 87% (95% confidential interval: 82.9-90.1) in intention-to-treat analysis. On days 4, 5, and 6, stool consistency was looser in the primary eradication failure group than in the success group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text