Bone turnover markers in relation to vitamin D status and disease activity in adults with systemic lupus erythematosus
| Autor: | Sharon Bout-Tabaku, V Mruk, A Sarkissian, S A Bowden, Stacy P. Ardoin, H Steigelman, K Morris, Vidya Sivaraman, Melissa Moore-Clingenpeel |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Osteoporosis Osteocalcin Severity of Illness Index Collagen Type I Bone remodeling Disease activity 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Vitamin D and neurology Humans Lupus Erythematosus Systemic Vitamin D 030203 arthritis & rheumatology biology business.industry Middle Aged medicine.disease C-telopeptide 030104 developmental biology Endocrinology biology.protein Female Bone Remodeling business Peptides Biomarkers |
| Zdroj: | Lupus. 28(2) |
| ISSN: | 1477-0962 |
| Popis: | Objective Patients with systemic lupus erythematosus (SLE) have altered bone metabolism and are at risk of osteoporosis. The aim of this study was to examine bone turnover markers in relation to vitamin D, disease activity, and clinical risk factors in patients with established SLE. Methods Clinical registry and biorepository data of 42 SLE patients were assessed. Serum samples were analyzed for osteocalcin as a marker of bone formation, C-terminal telopeptide of type 1 collagen (CTX) as a marker for bone resorption, and 25-hydroxy vitamin D. Results Patients with a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI) score of 3 or greater had a lower median osteocalcin level ( P = 0.02) and lower 25-hydroxy vitamin D levels ( P = 0.03) than those with a score of less than 3. No significant differences in bone turnover markers were observed between patients dichotomized into subgroups using a 25-hydroxy vitamin D cut-off of 30 ng/mL or by a daily prednisone dose greater than or 5 mg or less. Osteocalcin levels were negatively correlated with SLEDAI scores ( P = 0.034), and were positively correlated with the CTX index (a ratio of measured CTX value to the upper limit of the normal value for age and gender) ( P Conclusion SLE disease activity may have direct effects on bone formation, but no effects on bone resorption in this cohort of established SLE patients, probably related to the inflammation-suppressing effects of glucocorticoids, thereby inhibiting cytokine-induced osteoclast activity. A fine balance exists between disease control and the use of glucocorticoids with regard to bone health. |
| Databáze: | OpenAIRE |
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