Identification of New Players in Cell Division, DNA Damage Response, and Morphogenesis Through Construction of Schizosaccharomyces pombe Deletion Strains
| Autor: | Janel R. Beckley, Jürg Bähler, Danny A. Bitton, Nathan A. McDonald, Zachary C. Elmore, Nicholas Rhind, Sylvia J Jang, Kathleen L. Gould, MariaSanta C. Mangione, Nicole Rachfall, Michael A. Jensen, Alaina H. Willet, Anna Feoktistova, Christine M. Jones, Liping Ren, Rodrigo X. Guillen, Jun-Song Chen |
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| Rok vydání: | 2015 |
| Předmět: |
cell division
Cell division DNA damage Genes Fungal Saccharomyces cerevisiae Mutant Morphogenesis Investigations 03 medical and health sciences 0302 clinical medicine Schizosaccharomyces DNA metabolism Genetics Molecular Biology Gene Genetics (clinical) 030304 developmental biology 0303 health sciences biology gene deletion stress sensitivity biology.organism_classification fission yeast Schizosaccharomyces pombe 030217 neurology & neurosurgery DNA Damage |
| Zdroj: | G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| Popis: | Many fundamental biological processes are studied using the fission yeast, Schizosaccharomyces pombe. Here we report the construction of a set of 281 haploid gene deletion strains covering many previously uncharacterized genes. This collection of strains was tested for growth under a variety of different stress conditions. We identified new genes involved in DNA metabolism, completion of the cell cycle, and morphogenesis. This subset of nonessential gene deletions will add to the toolkits available for the study of biological processes in S. pombe. |
| Databáze: | OpenAIRE |
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