Preliminary investigations on the effects of a Strongylus vulgaris larval extract, mononuclear factors and platelet factors on equine smooth muscle cells in vitro
| Autor: | R. W. Storts, J. C. Lay, S. J. Morgan, P. C. Stromberg, B. A. Sowa |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Vascular smooth muscle Cell division Strongyle Infections Equine Vacuole Biology Lymphocyte Activation Muscle Smooth Vascular Antigen Internal medicine medicine Animals Platelet Horses Cells Cultured Arteritis General Veterinary General Medicine biology.organism_classification Molecular biology Strongylus In vitro Strongylus vulgaris Endocrinology Antigens Helminth Leukocytes Mononuclear Cell Division |
| Zdroj: | Veterinary Research Communications. 13:479-489 |
| ISSN: | 1573-7446 0165-7380 |
| Popis: | Factors involved in the proliferation of equine vascular smooth muscle cells were studied in vitro. The most prominent proliferative responses in cultured vascular smooth muscle cells were induced by Strongylus vulgaris larval antigen extract (LAE) and platelet-derived factors. Less significant proliferative responses were obtained with conditioned media from S. vulgaris LAE stimulated and from unstimulated equine mononuclear leukocytes. Additionally, vascular smooth muscle cells exposed to S. vulgaris LAE developed numerous perinuclear vacuoles and were more spindle-shaped than control or smooth muscle cells exposed to other factors. Equine mononuclear leukocytes exposed to LAE developed prominent morphological changes, including enlargement, clumping and increased numbers of mitotic figures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink