Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia
| Autor: | Mohammad Taheri, Iman Azari, Vahid Kholghi Oskooei, Seyedeh Morvarid Neishabouri, Hamid Fallah, Soudeh Ghafouri-Fard |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty lcsh:Medicine Molecular neuroscience Article 03 medical and health sciences Sex Factors 0302 clinical medicine Text mining Downregulation and upregulation Internal medicine medicine Humans Diagnostic biomarker lcsh:Science MEG3 MALAT1 Multidisciplinary business.industry lcsh:R Middle Aged medicine.disease Sex specific Peripheral blood Up-Regulation 030104 developmental biology Schizophrenia lcsh:Q Female RNA Long Noncoding Gene expression business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-49265-z |
| Popis: | Schizophrenia as a common disabling psychiatric disorder has been associated with dysregulation of several genes and pathways among them are those being regulated by long non-coding RNAs (lncRNAs). Based on the acknowledged roles of lncRNAs in neurodevelopment, in the current study, we assessed expression of six lncRNAs namely HOXA-AS2, Linc-ROR, MALAT1, MEG3, SPRY4-IT1 and UCA1 in peripheral blood of 60 patients with schizophrenia and 60 healthy subjects. HOXA-AS2, Linc-ROR, MEG3, SPRY4-IT1 and UCA1 levels were significantly higher in total patients compared with total controls. However, when evaluating expression of genes in sex-based subgroups, the differences in the expression of these lncRNAs were significant only among females. Assessment of partial correlation between expression of lncRNAs and age of study participants after controlling the effect of sex, revealed significant correlations for HOXA-AS2, MALAT1 and UCA1 in both patients and controls. Besides, expressions of Linc-ROR and SPRY4-IT1 were correlated with age only in patients. Significant pairwise correlations were recognized between expression levels of lncRNAs in both patients with schizophrenia and controls. Based on the area under curve (AUC) values, SPRY4-IT1 had the best performance in differentiation of female patients with schizophrenia from female controls (AUC = 0.85, P Linc-ROR, MEG3, SPRY4-IT1 and UCA1 expression levels could differentiate female patients with 95.2% sensitivity, 76.9% specificity and diagnostic power of 0.88 (P |
| Databáze: | OpenAIRE |
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