Impact of Histological and Endoscopic Remissions on Clinical Recurrence and Recurrence-free Time in Ulcerative Colitis
Autor: | Sónia Fernandes, Luísa Proença, Luís Alberto, João Carlos Silva, Joana Silva, Teresa Freitas, João Carvalho, S. Leite, Ana Ponte, Adélia Rodrigues, Jaime Rodrigues, Mafalda Sousa, Ana Paula Silva, Rolando Pinho |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Multivariate analysis medicine.medical_treatment Colonoscopy Kaplan-Meier Estimate Severity of Illness Index Gastroenterology Disease-Free Survival 03 medical and health sciences Remission induction 0302 clinical medicine Recurrence Internal medicine Severity of illness medicine Humans Immunology and Allergy Intestinal Mucosa Colitis Colectomy Aged Wound Healing medicine.diagnostic_test business.industry Remission Induction Middle Aged medicine.disease Ulcerative colitis 030220 oncology & carcinogenesis Clinical recurrence Multivariate Analysis Colitis Ulcerative Female 030211 gastroenterology & hepatology business Immunosuppressive Agents |
Zdroj: | Inflammatory Bowel Diseases. 23:2238-2244 |
ISSN: | 1078-0998 |
Popis: | Clinical and endoscopic remissions constitute the therapeutic goals in ulcerative colitis (UC). Histological healing is currently not a target in UC. This study aims to determine the impact of the definition of endoscopic remission (Mayo endoscopic subscore [MSe] 0-1) and histological activity in the recurrence of UC and recurrence-free survival time.Patients with UC in clinical remission (partial Mayo score ≤ 1) and endoscopic remission (MSe ≤ 1) who underwent colonoscopy with biopsies between March 2010 and December 2013 were included. The validated Nancy score was used to evaluate histological activity, which considers inactivity if 0 to 1 and activity if 2 to 4. The recurrence-free time was evaluated and recurrence was defined as partial Mayo score ≥ 2, therapy to induce remission, hospitalization, or colectomy. Predictive factors associated with recurrence and time to recurrence were determined.Sixty patients were included; 58.3% (n = 35) were women, with a mean age of 52.7 years. MSe = 1 was observed in 46.7% (n = 28) and histological activity in 38.3% (n = 23). Clinical recurrence occurred in 31.7% (n = 19) of patients, with a cumulative risk of 17.1%/24.5%/26.7%/40.1% at 12/24/36/48 months, respectively. MSe = 1 (P = 0.02) and histological activity (P = 0.007) were significantly associated with recurrence. Of these, only histological activity (P = 0.03) was an independent predictive factor of recurrence. Patients with MSe = 1 (P = 0.02) and with histological activity (P = 0.01) had a significantly shorter recurrence-free time in univariate analysis. In multivariate analysis, only histological activity (P = 0.02) was an independent predictive factor of lower recurrence-free time.The presence of histological activity represents an independent predictive factor of recurrence and time to recurrence, which was not verified with MSe 0 to 1. |
Databáze: | OpenAIRE |
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