Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release
| Autor: | M. Vasilescu, Cyrielle Rudaz, Tatiana Budtova, Diana Ciolacu |
|---|---|
| Přispěvatelé: | Laboratory of Natural Polymers, Bioactive and Biocompatible Materials, Petru Poni Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania (ICMPP), 'Petru Poni' Institute of Macromolecular Chemistry, Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Babes-Bolyai University [Cluj-Napoca] (UBB), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Polymers and Plastics
Kinetics 02 engineering and technology 010402 general chemistry 01 natural sciences [SPI.MAT]Engineering Sciences [physics]/Materials Crystallinity chemistry.chemical_compound [SPI]Engineering Sciences [physics] Polymer chemistry Materials Chemistry medicine Coagulation (water treatment) Controlled release Epichlorohydrin Cryogel Cellulose Anesthetics Local Swelling Dissolution Molecular Structure Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Hydrogel Drug Liberation Cross-Linking Reagents Chemical engineering chemistry Delayed-Action Preparations Cellulose Cross-linking Cryogel Hydrogel Swelling Controlled release medicine.symptom 0210 nano-technology Cryogels Procaine Cross-linking |
| Zdroj: | Carbohydrate Polymers Carbohydrate Polymers, Elsevier, 2016, 151, pp.392-400. ⟨10.1016/j.carbpol.2016.05.084⟩ |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2016.05.084⟩ |
| Popis: | International audience; Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated. |
| Databáze: | OpenAIRE |
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