A review of the anti‐inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes
Autor: | Amirhossein Sahebkar, Habib Yaribeygi, Stephen L. Atkin, Matteo Pirro |
---|---|
Rok vydání: | 2018 |
Předmět: |
Blood Glucose
0301 basic medicine Physiology medicine.drug_class Inflammatory response medicine.medical_treatment Clinical Biochemistry hypoglycemic agents Inflammation tumor necrosis factor α (TNF-α) Bioinformatics Anti-inflammatory Diabetes Complications 03 medical and health sciences 0302 clinical medicine Diabetes mellitus diabetes mellitus (DM) cytokine diabetic complications medicine Humans diabetic nephropathy (DN) Antidiabetic agents business.industry Type 2 Diabetes Mellitus Cell Biology medicine.disease Pathophysiology Glucose 030104 developmental biology Cytokine Diabetes Mellitus Type 2 Cardiovascular Diseases inflammation 030220 oncology & carcinogenesis medicine.symptom business |
Zdroj: | Journal of Cellular Physiology. 234:8286-8294 |
ISSN: | 1097-4652 0021-9541 |
Popis: | The global prevalence of Type 2 diabetes mellitus and its associated complications are growing rapidly. Although the role of hyperglycemia is well recognized in the pathophysiology of diabetic complications, its exact underlying mechanisms are not fully understood. In this regard, accumulating evidence suggests that the role of inflammation appears pivotal, with studies showing that most diabetic complications are associated with an inflammatory response. Several classes of antidiabetic agents have been introduced for controlling glycemia, with evidence that these pharmacological agents may have modulatory effects on inflammation beyond their glucose-lowering activity. Here we review the latest evidence on the anti-inflammatory effects of commonly used antidiabetic medications and discuss the relevance of these effects on preventing diabetic complications. |
Databáze: | OpenAIRE |
Externí odkaz: |