Vitreoretinal lymphomas misdiagnosed as uveitis: Lessons learned from a case series

Autor: Matteo Belpoliti, Alfonso Iovieno, Marco Coassin, Andrea Fanti, Luca Cimino, Chi-Chao Chan, Luigi Fontana, Sylvia Marchi
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
intraocular inflammation
Vitrectomy
Subretinal infiltrates
0302 clinical medicine
lcsh:Ophthalmology
Intraocular Lymphoma
Pathognomonic
Sampling (medicine)
Aged
80 and over
vitreoretinal lymphoma
Middle Aged
Original Article
Female
Intraocular lymphoma
Diagnostic vitrectomy
Intraocular inflammation
Uveitis
Vitreoretinal lymphoma
Tomography
Optical Coherence
medicine.medical_specialty
Retinal Neoplasm
Retinal Neoplasms
Enzyme-Linked Immunosorbent Assay
03 medical and health sciences
medicine
Biomarkers
Tumor
Humans
Diagnostic Errors
Aged
Retrospective Studies
business.industry
Interleukins
Retrospective cohort study
medicine.disease
Occult
Dermatology
Surgery
Vitreous Body
Ophthalmology
030104 developmental biology
subretinal infiltrates
lcsh:RE1-994
030221 ophthalmology & optometry
business
Follow-Up Studies
Zdroj: Europe PubMed Central
Indian Journal of Ophthalmology
Indian Journal of Ophthalmology, Vol 64, Iss 5, Pp 369-375 (2016)
Popis: Purpose: To present challenging cases of vitreoretinal lymphoma (VRL) that was misdiagnosed as uveitis because of the apparent intraocular inflammation. At the light of the new classification of intraocular lymphomas, we detail the characteristics that masqueraded the tumors and the clinical aspects that guided us to the correct diagnosis. Materials and Methods: We retrospectively reviewed the patients referred to our uveitis service between January 2006 and December 2014. Results: Seven patients referred with a presumptive diagnosis of idiopathic uveitis received a final diagnosis of VRL. The median time between the onset of symptoms and definitive diagnosis was 25 months for these complex cases. The median time from presentation at our clinic to final diagnosis was 1 month. The described clinical features including dense vitreous cells and subretinal infiltrates were characteristic and tend to be present in all these chronically ill patients. Vitreous samples were collected, and all demonstrated the pathognomonic tumor cells, the specific immunoglobulin heavy chain gene rearrangements, and an interleukin (IL)-10 to IL-6 ratio >1. Conclusion: VRLs are severe diseases with a poor prognosis that may be misdiagnosed as idiopathic inflammatory conditions of the eye. Treatment with steroids may occult the tumors and delay the correct diagnosis. Appropriate evaluation may prompt to a timely vitreous sampling and therefore to a faster diagnosis in these peculiar cases where the correct diagnosis was delayed by several months.
Databáze: OpenAIRE
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