Nucleotide Sequence of the 5′ Noncoding Region of Hepatitis G Virus Isolated from Japanese Patients: Comparison with Reported Isolates
| Autor: | Ishiyama N, A Oya, Hirofumi Okamura, Shuetsu Fukushi, Kazuhiko Katayama, Fuminori B. Hoshino, Chie Kurihara |
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| Rok vydání: | 1996 |
| Předmět: |
Genotype
Hepatitis Viral Human Hepatitis C virus Molecular Sequence Data Biophysics HCV genotypes Biology medicine.disease_cause Polymerase Chain Reaction Biochemistry Virus Japan Sequence Homology Nucleic Acid Hepatitis Viruses medicine Humans Molecular Biology Phylogeny DNA Primers Genetics Base Sequence Phylogenetic tree Nucleic acid sequence virus diseases Cell Biology Virology digestive system diseases Hepatitis G Sequence identity RNA Viral |
| Zdroj: | Biochemical and Biophysical Research Communications. 226:314-318 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1996.1353 |
| Popis: | The nucleotide sequences of the 5′ noncoding region (NCR) of hepatitis G virus (HGV) from sera of Japanese patients were determined. Among these isolates, there was a high degree (>96.9%) of sequence identity, whereas identity with previously reported GB virus-C or HGV strains was low (>87.0%). Phylogenetic analyses showed that the HGV strains from Japanese patients clustered in groups distantly separated from previously reported strains. Among the Japanese HGV isolates, the genetic distances corresponded to subtype differences observed within hepatitis C virus (HCV) isolates, whereas the differences between the Japanese isolates and the prototypes corresponded to genetic distances observed between HCV genotypes. The Japanese HGV isolates found in this study should be placed in a new genotype distinct from previously described isolates. |
| Databáze: | OpenAIRE |
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