Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
| Autor: | Mojtaba Falahati, Majid Sharifi, Yu Cai, Tiange Cai, Amir Jouya Talaei, Fansu Meng, Mohammad Mahdi Nejadi Babadaei, Anwarul Hasan, Pegah Hashemi Kani |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Fabrication Materials science Biocompatibility Nanotechnology Microneedle array Biodegradable polymers Article Fabrication method 03 medical and health sciences 0302 clinical medicine lcsh:Science (General) Transdermal ComputingMethodologies_COMPUTERGRAPHICS lcsh:R5-920 Multidisciplinary technology industry and agriculture Biodegradable polymer Dissolving polymers 030104 developmental biology Hydrogel polymers 030220 oncology & carcinogenesis Drug delivery Drug release lcsh:Medicine (General) lcsh:Q1-390 |
| Zdroj: | Journal of Advanced Research, Vol 26, Iss, Pp 137-147 (2020) Journal of Advanced Research |
| ISSN: | 2090-1232 |
| Popis: | Graphical abstract Background Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). Aim of Review Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. Key Scientific Concepts of Review This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect. |
| Databáze: | OpenAIRE |
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