Two-Step Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole-Containing Cyclopeptides

Autor:	Jason E. Fenwick, Adel Nefzi, Sergey Arutyunyan
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Molecular Structure Intramolecular reaction Organic Chemistry Two step Peptides Cyclic Chemical synthesis Combinatorial chemistry Cyclic peptide Thiazoles chemistry.chemical_compound Nucleophile chemistry Cyclization Intramolecular force Molecule Thiazole
Zdroj:	The Journal of Organic Chemistry. 75:7939-7941
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo1016822
Popis:	Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in high purities and good overall yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0667ddd317ef1dc51b1b975ff909a846 https://doi.org/10.1021/jo1016822 Zobrazit plný text záznamu