| Autor: |
Cyril O. Erameh, Temitope Farombi, Uchechi Agulanna, Funlola T. Taiwo, Ohwotemu Arigbodi, Morenikeji Komolafe, John E. Akpekpe, Babawale Arabambi, Nosakhare Osemwegie, Emmanuel E. Obehighe, Babatunde Ademiluyi, Olajumoke Oshinaike, SA Abubakar, Charles O. Achoru, Abiodun H Bello, Akintunde A Adebowale, Njideka U Okubadejo, Rufus Akinyemi, Shyngle I. Oyakhire, Kolawole Wahab, E U Iwuozo, Olanike A. Odeniyi, Bertha C. Ekeh, Michael B. Fawale, Ifeyinwa Ani-Osheku, Gerald A. Onwuegbuzie, Oladunni V. Abiodun, Mie Rizig, Frank Aiwansoba Imarhiagbe, Yakub Wilberforce Nyandaiti, Franklin O Dike, Ernest O. Nwazor, Folajimi M. Otubogun, Paul O Nwani, Yusuf A. Zubair, Salisu A. Balarabe, Oluwadamilola O. Ojo, Yahaya Obiabo, Godwin Osaigbovo, O. S. Ekenze, Francis E Odiase, Mohammed W. Ali, Francis I Ojini, Osigwe P. Agabi, Abiodun J. Kehinde, Christian E. Agu, U. E. Williams, Olaleye Adeniji |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Mov Disord Clin Pract |
| ISSN: |
2330-1619 |
| Popis: |
BACKGROUND: Data on non‐motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse. OBJECTIVE: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype. METHODS: We conducted a cross‐sectional study of the frequency and burden of NMS, based on the non‐motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS‐UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented. RESULTS: Data are presented for 825 PD whose mean age at study was 63.7 ± 10.1 years, female sex—221 [26.8%] while median PD duration was 36 months. PD phenotypes included tremor‐dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500 mg/24 hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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