Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease
| Autor: | Alexander Peden, Diane Ritchie, James W. Ironside, Mark Head, Helen Yull, Richard Bonshek, Andrew B Tullo |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty PrPSc Proteins genetic structures animal diseases Blotting Western Clinical Science - Scientific Reports Biology Creutzfeldt-Jakob Syndrome Retina Central nervous system disease Cellular and Molecular Neuroscience chemistry.chemical_compound Degenerative disease mental disorders medicine Humans Aged Paraffin Embedding Retinal medicine.disease Immunohistochemistry Virology Sensory Systems nervous system diseases Blot Ophthalmology medicine.anatomical_structure chemistry sense organs |
| Zdroj: | Head, M W, Peden, A H, Yull, H M, Ritchie, D L, Bonshek, R E, Tullo, A B & Ironside, J W 2005, ' Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease ', British Journal of Ophthalmology, vol. 89, no. 9, pp. 1131-3 . https://doi.org/10.1136/bjo.2004.063495 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2004.063495 |
| Popis: | Background: Involvement of the eye has been reported in patients with variant Creutzfeldt-Jakob disease (vCJD), but there is disagreement on whether retinal involvement occurs in sporadic Creutzfeldt-Jakob disease (sCJD). Methods: Western blotting, paraffin embedded tissue blotting, and immunohistochemistry were used to test whether the abnormal form of the prion protein (PrPSc) accumulates to detectable levels in the eye in a case of the most common subtype of sCJD (MM1). Results: Low levels of PrPSc were detectable in the retina, localised to the plexiform layers of the central retina. PrPSc was not detectable in other ocular tissues. Conclusions: The abnormal form of the prion protein is present in the retina in the most common sCJD subtype (MM1), albeit at levels lower than those found previously in vCJD and in sCJD of the VV2 subtype. |
| Databáze: | OpenAIRE |
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