Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder
| Autor: | Maiko Abel Schneider, Grasiela Marcon, Luiza Nunes Pereira Lima, André Quincozes-Santos, Joao Pedro Abreu da Silva, Flávio Kapczinski, Diego Librenza-Garcia, Marcia Kauer-Sant Anna, Jairo Vinícius Pinto, Ives Cavalcante Passos, Joao Henrique Conte |
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| Rok vydání: | 2017 |
| Předmět: |
Bipolar Disorder
glia Excitotoxicity microglia Cell Communication medicine.disease_cause Article Treatment of bipolar disorder Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine mania astrocyte Glutamate homeostasis medicine Animals Humans Pharmacology (medical) Bipolar disorder Neuroinflammation Pharmacology Neurons Microglia business.industry General Medicine medicine.disease neuron 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Neurology brain-blood barrier Cytokines Neurology (clinical) Neuron sense organs business Neuroscience Neuroglia 030217 neurology & neurosurgery oligodendrocyte |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1875-6190 |
| Popis: | Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder. |
| Databáze: | OpenAIRE |
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