Effects and Mechanism of Noninvasive Positive-Pressure Ventilation in a Rat Model of Heart Failure Due to Myocardial Infarction
| Autor: | He Jiang, Fumei Zhao, Ting Liu, Qingliang Chen, Jie Geng, Shan Liu, Yuhua Rui, Yanqiu Song, Chao Chang, Zhigang Zuo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Positive-Pressure Respiration Left coronary artery Fibrosis medicine.artery Internal medicine medicine Animals HSP70 Heat-Shock Proteins Myocardial infarction Rats Wistar Heart Failure Ventricular Remodeling Tumor Necrosis Factor-alpha business.industry Myocardium Animal Study General Medicine Brain natriuretic peptide medicine.disease Rats Disease Models Animal Matrix Metalloproteinase 9 Embolism Echocardiography Heart failure Cardiology Breathing Matrix Metalloproteinase 2 Myocardial fibrosis Cardiomyopathies business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.928476 |
| Popis: | BACKGROUND Impaired heart function induced by myocardial infarction is a leading cause of chronic heart failure (HF). This study aimed to investigate the effects and mechanism of noninvasive positive-pressure ventilation (NIPPV) in a rat model of HF due to myocardial infarction. MATERIAL AND METHODS To explore the therapeutic effect and mechanism of NIPPV on acute myocardial infarction-induced HF, we established a rat model of HF by ligating the anterior descending branch of the left coronary artery and confirmed by ultrasonic cardiography and brain natriuretic peptide 45 detection. RESULTS The levels of heat-shock protein (HSP)-70 increased and matrix metalloproteinase (MMP)-2, MMP-9, and tumor necrosis factor (TNF)-alpha decreased in the group that received NIPPV treatment compared with the control group. In addition, the histopathologic results showed less severe inflammatory infiltration and a smaller area of myocardial fibrosis in the NIPPV treatment group. CONCLUSIONS In a rat model of HF due to myocardial infarction, NIPPV resulted in increased levels of HSP70 and reduced expression of MMP2, MMP9, and TNF-alpha and reduced myocardial neutrophil infiltration and fibrosis. Taken together, we showed that NIPPV is an effective treatment for HF induced by myocardial infarction by inhibiting the release of inflammatory factors and preventing microvascular embolism. |
| Databáze: | OpenAIRE |
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