Congenital surfactant protein B deficiency - emphasis on imaging
| Autor: | Beverley Newman, J. P. Kuhn, Joseph A. Carcillo, Sandra S. Kramer |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty Proteolipids Alveolar proteinosis Pulmonary Alveolar Proteinosis Extracorporeal Membrane Oxygenation Pulmonary surfactant Surfactant Protein B Deficiency Humans Medicine Radiology Nuclear Medicine and imaging Protein Precursors Neuroradiology medicine.diagnostic_test Respiratory distress business.industry Respiratory disease Infant Newborn Infant medicine.disease Bronchoalveolar lavage Mutation Pediatrics Perinatology and Child Health Female Tomography X-Ray Computed business Complication |
| Zdroj: | Pediatric Radiology. 31:327-331 |
| ISSN: | 1432-1998 0301-0449 |
| DOI: | 10.1007/s002470100438 |
| Popis: | Background and objectives. Surfactant protein B deficiency has become increasingly recognized as a cause of severe prolonged respiratory distress. Little has been written about the imaging appearance and the role of imaging in diagnosis. Materials and methods. Three newborn infants with severe respiratory distress exhibited prolonged diffuse pulmonary opacification radiographically. Results. Diffuse ground-glass opacity and markedly prominent interlobular septa suggesting alveolar proteinosis were present on early thin-section chest computed tomographic (CT) images. Fibrotic changes with prominent interlobular septal thickening were present on a later CT. Surfactant protein B deficiency was confirmed by alveolar lavage and peripheral blood DNA analysis. Conclusion. Thin-section chest CT imaging contributes important information when this diagnosis is considered. |
| Databáze: | OpenAIRE |
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